Intermediate of Ilaprazole CAS NO.172152-35-1

Hebei BRANT Pharmaceutical Co Ltd is engaging in R&D&I and manufacture of pharmaceutical intermediates and API. We are specialized in chiral synthesis and resolution, total synthesis, enzyme catalytic reaction and process control technology. 
    BRANT Pharmaceutical has a production base, a collaborating API production base, a R&D center and a university research lab. 
   BRANT has formed one set of modern enterprise management mechanism, innovation mechanism, performance appraisal and incentive mechanism, thus to achieve improvements to research system, production management system and market operation system. In the enterprise, all production and management and operation system are guided by GMP regulations. The company has been certificated with ISO9001:2008 Quality System Certification, ISO14001 Environmental Management System certificate and OHSAS18000 Occupational Health and Safety System.

PLANT FACILITIES

Advantages of manufacturing service
 · Products with superior quality manufactured by experienced production team with completed facilities, under direction of innovative and effective R&D team, in standard enlarging mode of lab trial – pilot trial – commercial production, under rules of GMP regulations, which guarantee the rapid transformation from R&D results to commercial productions.
 · Multi-modes of manufacturing service including production for regular orders, customized manufacture, cooperative R&D, cooperative production, consigned processing, processing with supplied material, consigned R&D, and undertake outsourcing contacts.
 · Perfect systems of communication with customers and feedback of information.
 · Attentive pre-sale, in-sale and after-sale services.
 · Responsible service team with well trained stuff of technology and operations.
 · Base of suppliers with reliable quality of raw material, excellent reputation and credit, prompt guaranty.

Introduction of pilot factories and manufacturing factories
 · One pilot factory and three manufacturing factories with seven multi-functioned production lines, equipped with more than one hundred of reactors in material of glass-lined, carbon steel and stainless steel, as well as full set of transforming facility of biological enzyme catalysis. Capacity of reactors covers the range from 50-500L (in pilot factory) and 1000-6300L (in manufacturing factories), guarantees production from grade of kilogram to tonnages of commercial manufacture.
 · Completed regular synthetic units and chemical engineering units including extraction, dropping, distillation, rectification, filtering, drying and refined-finishing areas.
 · Guarantees to implement synthetic reaction under conditions of various temperatures: 5~20oC, 30~100oC, 130~250oC, as well as low temperature reaction (or crystallization) between -40~0oC.
 ·  Auxiliary facilities including reacting units of hydrogenation, measuring, distillation, vacuum, rectification, drying, hot-oil, steam supply, filtering, centrifuge, purified water, DCS monitor, waste gas monitor, nitrogen generator and chilling water generator. 
 
Common utilities
 · Warehouses for solid material, liquid material (in addition to liquid storage tanks), finished products under normal temperature and low temperature.
 · Power supply is supported by dual-loop system, with distributing units of high and low voltage, as well as electric power generator.
 · Refrigerating water generators, stable supply of chilling water of -150C and -400C.
 · Automatic water supply device with purified water supply and circulating water pumps, as well as fire-protection pumps and pools.
 ·  Steam supply of boilers, guarantees effective heat exchange between steam and hot water.
 ·  Ordinary water injection vacuum pumps and Roots water injection vacuum pumps, which achieve operating system of ultimate vacuum.
 · Taking oil-free air compressors as resources, the ultra-pure nitrogen generators ensure a full protection to all processes of manufacture.
 ·  Biological and physical and chemical waste water disposal system, guarantees treated waste water reaching national standard and discharging into municipal network. Full set of falling film absorbers guarantee tail gas to be exhausted complying to standards.